The_Allergy_Pathway.jpg
Size of this preview:
800 × 508 pixels
.
Other resolutions:
320 × 203 pixels
|
640 × 407 pixels
|
1,024 × 650 pixels
|
1,280 × 813 pixels
|
2,122 × 1,348 pixels
.
This image was
uploaded
in the
JPEG
format even though it
consists of non-photographic data
. This information could be stored more efficiently or accurately in the
PNG
or
SVG
format.
If possible, please upload a PNG or SVG version of this image without
compression artifacts
, derived from a non-JPEG source (or with existing artifacts
removed
). After doing so, please tag the JPEG version with
{{Superseded|NewImage.ext}}
and remove this tag. This tag should not be applied to photographs or scans. If this image is a diagram or other image suitable for
vectorisation
, please tag this image with
{{Convert to SVG}}
instead of
{{BadJPEG}}
. If not suitable for vectorisation, use
{{Convert to PNG}}
. For more information, see
{{BadJPEG}}
.
|
Summary
Description The Allergy Pathway.jpg |
English:
Simplified diagram showing key events that leads to allergy initiation.
A.
the allergen enters the body.
B.
an
Antigen-presenting cell
takes up the allergen molecule and presents its
epitopes
, through the
MHC II receptor
, onto its surface. The activated antigen presenting cell then migrates to the nearest lymph node
C.
where it activates T cells that recognize the allergen. They then give the decision for the T cell to differentiate to
Th2 cell
.
D.
at the same time, B cells recognize the allergen and through the activated Th2 cell
E.
the B cell would be activated.
F.
and differentiate into plasma cells, at which point they would actively synthesize antibodies of the
IgE
isotype.
G.
the IgE antibody, that now recognizes epitopes of the allergen molecule, circulates around the body through the
lymphatic
and
cardiovascular systems
and finally binds to its
FcεRI
receptor on mast and basophil cells.
H.
when the allergen re-enters the body at a later time it binds to the IgE, which is on the cell surface, resulting in an aggregation of the receptor causing the cells to release pre-formed mediators. One of these mediators is
histamine
which causes the 5 symptoms of allergic inflammation: heat, pain, swelling, redness and itchiness. Another mediator is IL-4, which affects more B cells to differentiate into plasma cells and produce more IgE and thus the vicious cycle continues.
|
Date | |
Source | Sabban, Sari (2011) Development of an in vitro model system for studying the interaction of Equus caballus IgE with its high- affinity FcεRI receptor (PhD thesis), The University of Sheffield |
Author | SariSabban |
Other versions |
|
Licensing
I, the copyright holder of this work, hereby publish it under the following license:
This file is licensed under the
Creative Commons
Attribution-Share Alike 3.0 Unported
license.
-
You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
-
Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- share alike – If you remix, transform, or build upon the material, you must distribute your contributions under the same or compatible license as the original.