TRPC5_Chemo.jpg
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English:
Two distinct TRPC5 mediated the cancer drug resistance. (a) TRPC5 overexpression activates the transcription factor NFATC3 Ca2+ signaling pathway, leading to p-gp overexpression. Moreover, the overexpressed p-gp expels chemotherapeutic drugs triggering chemoresistance. (b) Chemoresistant breast cancer cells overexpressing TRPC5 transfer channel units to chemo sensitive recipient cells via extracellular vesicles (EV), leading to the development of TRPC5-mediated chemoresistance in these cells.
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| Date | |
| Source | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536409/ |
| Author | Mayar Soussi, Alice Hasselsweiller, and Dimitra Gkika |
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