Substrate-targeting_sites_on_cyclin–Cdk_complexes.pdf
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Summary
| Description |
English:
The central substrate-recognition site on Cdks lies in the active-site T-loop, which interacts with the SPXK consensus sequence that contains the phosphorylation site (see Figure 3-12). An RXL motif in some substrates interacts with the hydrophobic patch on the cyclin, thereby enhancing the rate of phosphorylation. The presence of a phosphate-binding pocket on the accessory subunit Cks1 may facilitate interactions with targets that contain multiple phosphorylation sites.
[1]
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| Date | |
| Source | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248297/ |
| Author | David O Morgan |
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