Replication_stress_and_its_consequences_in_mitosis.png
Size of this preview:
412 × 599 pixels
.
Other resolutions:
165 × 240 pixels
|
330 × 480 pixels
|
528 × 768 pixels
|
704 × 1,024 pixels
|
2,200 × 3,200 pixels
.
Summary
| Description |
English:
Replication stress from either endogenous or exogenous causes (red circles) leaves chromosomal segment unreplicated or interwinded leading to anaphase bridges formation. Single-ended DSB could lead to dicentric chromosome formation and thus, also, to anaphase bridge formation. Non-detected damages upon low replicative stress could be grouped in one detectable entity in G1: 53BP1 bodies and/or micronuclei. Replication stress also favors mitotic extra centrosomes and multipolar mitosis, thus amplifying mitotic catastrophes and genome instability to the whole genome.
[1]
|
| Date | |
| Source | https://doi.org/10.3390/genes6020267 |
| Author | Camille Gelot, Indiana Magdalou, and Bernard S. Lopez |
Licensing
This file is licensed under the
Creative Commons
Attribution 4.0 International
license.
-
You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
-
Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.