R-loop_promoting_factors.jpg
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Summary
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English:
Negative supercoiling promotes R-loop formation. Topoisomerases inhibit R-loop formation by resolving negative supercoiling. The presence of a nick in the nontemplate strand downstream of a promoter makes DNA reannealing less efficient, which favors nucleation of an R-loop. DNA secondary structures can also stabilize the R-loop structures. G-clusters on the RNA transcript favor R-loop formation. Defects in anti-R-loop factors like RNase H and RNA-DNA helicases also lead to increased R-loop formation.
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| Date | |
| Source | Hegazy, Y. A., Fernando, C. M., & Tran, E. J. (2020). The balancing act of R-loop biology: The good, the bad, and the ugly. Journal of Biological Chemistry, 295(4), 905-913. |
| Author | Hegazy, Y. A., Fernando, C. M., & Tran, E. J. |
| Other versions | Derivative works of this file: R-loop factors rus.png |
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