Mambalgin.png
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Summary
Description Mambalgin.png |
English:
The crystal structure of mambalgin-1, a 57-residue protein of the three-finger toxin (3FTx) family isolated from the venom of the black mamba. Mambalgins are potent inhibitors of acid-sensing ion channels. Unlike most 3FTx proteins, which are usually neurotoxins, mambalgins produce analgesia through ASIC inhibition without apparent toxic effect in laboratory tests.
Mourier, Gilles; Salinas, Miguel; Kessler, Pascal; Stura, Enrico A.; Leblanc, Mathieu; Tepshi, Livia; Besson, Thomas; Diochot, Sylvie; Baron, Anne (2016-02-05). "Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition". Journal of Biological Chemistry. 291 (6): 2616–2629. doi:10.1074/jbc.m115.702373. PMC 4742732.
PMID 26680001
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Date | |
Source | Own work ; PDB : 5DU1 ; PMID 26680001 . |
Author | Opabinia regalis |
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