Hypothetic_models_of_VAMP2_conformations_and_engagement_in_SNARE_complex_assembly_for_neurotransmitter_release.pdf
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Summary
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English:
The extravesicular domain of VAMP2 adopts distinctive conformations in different membrane regions. On the cholesterol-rich microdomains, it is less associated with synaptic vesicle membrane and thus more active to engage in calcium-evoked SNARE assembly and neurotransmitter release. In contrast, in other regions of synaptic vesicle membrane, it tends to hibernate on the membrane with an increased content of α-helical conformation which is relatively inactive in SNARE assembly.
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| Date | |
| Source | https://doi.org/10.1038/s41467-020-15270-4 |
| Author | Chuchu Wang, Jia Tu, Shengnan Zhang, Bin Cai, Zhenying Liu, Shouqiao Hou, Qinglu Zhong, Xiao Hu, Wenbin Liu, Guohui Li, Zhijun Liu, Lin He, Jiajie Diao, Zheng-Jiang Zhu, Dan Li & Cong Liu |
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