Basal_ganglia_in_treatment_of_Parkinson's.png
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Summary
Description Basal ganglia in treatment of Parkinson's.png |
English:
Circuits of the
basal ganglia
in treatment of
Parkinson's disease
.
Levodopa
,
dopamine agonists
and
MAO-B inhibitors
stimulate excitatory signals from the
thalamus
to the
cortex
by effects on the
striatum
, compensating for decreased dopaminergic signals from
substantia nigra
(seen at bottom right). Picture shows 2 coronal slices that have been superimposed to include the involved basal ganglia structures. + and - signs at the point of the arrows indicate respectively whether the pathway is excitatory or inhibitory in effect.
Green arrows
refer to excitatory
glutamatergic
pathways,
red arrows
refer to inhibitory
GABAergic
pathways and
turquoise arrows
refer to
dopaminergic
pathways that are excitatory on the direct pathway and inhibitory on the indirect pathway. Dis-inhibitory pathways are in effect excitatory on the feedback to the cortex, while dis-dis-inhibitory pathways are inhibitory.
|
Date | |
Source | Derivative of File:Basal ganglia circuits.png |
Author | Mikael Häggström , based on image by Andrew Gillies/ User:Anaru |
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Basal ganglia gallery
-
Basal ganglia without Parkinson's disease.png .
(Derived from Basal ganglia circuits.svg with small change)
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