Template:Classification_of_estrogens_and_antiestrogens_by_receptor–estrogen_complex_retention

Template:Classification of estrogens and antiestrogens by receptor–estrogen complex retention

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Class	Examples	RE complex retention	Pharmacodynamic profile	Uterine effects
Short-acting (a.k.a. "weak" or "impeded")	Estriol • 16-Epiestriol • 17α-Estradiol • ent-Estradiol • 16-Ketoestradiol • Dimethylstilbestrol • meso-Butestrol	Short (1–4 hours)	Single or once-daily injections: partial agonist or antagonist	Early responses^a
Short-acting (a.k.a. "weak" or "impeded")		Short (1–4 hours)	Implant or multiple injections per day: full agonist	Early and late responses^b
Long-acting	A. Estradiol • Estrone • Ethinylestradiol • Diethylstilbestrol • Hexestrol	Intermediate (6–24 hours)	Single or once-daily injections: full agonist	Early and late responses
Long-acting	B. Clomifene • Nafoxidine • Nitromifene • Tamoxifen	Long (>24–48 hours)	Single injection: agonist Repeated injections: antagonist	Early and late responses
Footnotes: ^a = Early responses occur after 0–6 hours and include water imbibition, hyperemia, amino acid and nucleotide uptake, activation of RNA polymerases I and II, and stimulation of induced protein, among others. ^b = Late responses occur after 6–48 hours and include cellular hypertrophy and hyperplasia and sustained RNA polymerase I and II activity, among others. Sources: ^[1]^[2]^[3]^[4]^[5]^[6]^[7]

Template:Classification of estrogens and antiestrogens by receptor–estrogen complex retention