Dimethylstilbestrol
Dimethylstilbestrol
Chemical compound
Dimethylstilbestrol (DMS) is a nonsteroidal estrogen of the stilbestrol group related to diethylstilbestrol which was never marketed.[1][2][3][4][5]: 213 It is a so-called "weak", "impeded", or "short-acting" estrogen similarly to estriol and meso-butoestrol.[6][7][8][9] The affinity of DMS for the ER was reported as about 10% of that of estradiol.[10] For comparison, diethylstilbestrol had 140% of the affinity of estradiol for the ER.[10]
The endometrial proliferation dose of DMS in women is 20 mg.[5]: 212–213 A single 12 mg intramuscular injection of DMS has a duration of approximately 12 days in humans.[5]