Route 22 is a highway in central Missouri. Its eastern terminus is at U.S. Route 54 in Mexico; its western terminus is at U.S. Route 63 south of Clark on the Randolph/Boone county line. Route 22 was one of the original 1922 state highways and originally had an eastern terminus at Route 9 (now U.S. Route 61) in Louisiana. This section was replaced by U.S. Route 54 in 1926.

Quick Facts Route 22, Route information ...

Route 22
Route information
Maintained by MoDOT
Length	28.797 mi[1] (46.344 km)
Existed	1922–present
Major junctions
West end	US 63 / Route F south of Clark
East end	US 54 / US 54 Bus. / Route 15 in Mexico
Location
Country	United States
State	Missouri
Highway system
Missouri State Highway System Interstate US State Supplemental
← Route 21 → Route 23

Close

Route 22 begins at a junction of US Route 63 east of Sturgeon. Route 22 passes north of Sturgeon. Strugeon can be accessed by taking Route V. Route 22 picks up a concurrent with Route 151 for a little bit before passing through Centralia where it met the terminus of Route 151 and Route 124. Next, it passes through Thompson. Then, it passes through Mexico. Through Mexico, it will pick a concurrency with US Route 54 Business Route and Route 15. After leaving Mexico, Route 22 along with US Route 54 Business Route and Route 15 ends at a junction of US Route 54.^[2]