The year 1822 in science and technology involved some significant events, listed below.

• "Rostocker Pfeilstorch", a white stork, is found in northern Germany with an arrow from central Africa through its neck, demonstrating the fact of bird migration.

• Georges Cuvier establishes new standards and methods in stratigraphy and paleontology.
• Gideon Mantell discovers the first fossil of the iguanodon.
• John Phillips and William Conybeare identify the Carboniferous Period.
• Jean Baptiste Julien d'Omalius d'Halloy identifies the Cretaceous Period. He also proposes the Jurassic System.

• July 3 – Charles Babbage publishes a proposal for a "difference engine", a mechanical forerunner of the modern computer for calculating logarithms and trigonometric functions. Construction of an operational version will proceed under British Government sponsorship 1823–32 but it will never be completed.^[1]
• Karl Feuerbach describes the nine-point circle of a triangle.^[2]
• William Farish of the University of Cambridge publishes a systematization of the rules for isometric drawing.^[3][4][5]

• United States Army surgeon William Beaumont pioneers human gastric endoscopy on Alexis St. Martin.^[6]
• Scottish surgeon John Henry Wishart gives the first description in England of neurofibromatosis type II.^[7][8]

• Navier–Stokes equations in fluid dynamics first formulated.

• May 23 – HMS Comet launched at Deptford Dockyard in the United Kingdom, the first steamboat commissioned by the Royal Navy.
• June 10 – The Aaron Manby crosses the English Channel, making her the first seagoing iron steamboat.
• French civil engineer Louis Vicat completes construction of a concrete viaduct across the Dordogne at Souillac, Lot.^[9]

• September 11 – Galileo's Dialogue Concerning the Two Chief World Systems (1632) is permitted by the Roman Catholic Church to be published.

• June 12 – Edward Banks knighted, the first such honour for work in civil engineering.^[10]
• Copley Medal: William Buckland^[11]

• January 2 – Rudolf Clausius, German physicist (died 1888)
• January 6 – Heinrich Schliemann, German archaeologist (died 1890)
• January 12 – Étienne Lenoir, Belgian mechanical engineer (died 1900)
• February 16 – Sir Francis Galton, English explorer, biologist (died 1911)
• April 18 – August Heinrich Petermann, German cartographer (died 1878)
• June 10 – Lydia White Shattuck, American botanist (died 1889)
• July 22 – Gregor Mendel, Silesian geneticist (died 1884)
• October 13 (O.S. October 1) – Lev Tsenkovsky, Polish-Ukrainian biologist (died 1887)
• December 27 – Louis Pasteur, French biologist (died 1895)

• January 21 – Marie-Aimée Lullin, Swiss entomologist (born 1751)
• February 23 – Johann Matthäus Bechstein, German naturalist (born 1757)
• June 23 – René Just Haüy, French mineralogist (born 1743)
• August 13 – Jean-Robert Argand, Swiss-born mathematician (born 1768)
• August 25 – William Herschel, German-born British astronomer (born 1738)
• November 6 – Claude Louis Berthollet, French chemist (born 1748)