WBC Super Bantamweight Championship

In 2001, Larios challenged undefeated WBC Super Bantamweight title holder Willie Jorrín and lost a disputed 12-round decision. Due to Jorrin's lack of activity, Larios fought Vázquez for the interim WBC Super Bantamweight Title and his earlier loss to Vázquez by scoring a TKO in the 12th round. Several months later, Larios again took on Jorrin and avenged the earlier defeat by defeating Jorrin by TKO in the 1st round.

Larios went on to defend his title 7 times (along with 3 non-title fights), including a victory over Nedal Hussein and two wins over fan favorite Wayne McCullough. He then took on Vázquez yet again but was dominated this time, dropping the trilogy capper by KO 3 and thus losing his title. In July 2006, Larios moved up to Super Featherweight to take on then three-division world champion Manny Pacquiao, a Filipino boxer highly capable of besting opponents by KO. Larios fought bravely, but was dominated by the bigger Pacquiao and was dropped twice en route to losing a 12-round decision.

Move to Featherweight

WBC Featherweight Championship

Larios inherited the full-pledge WBC featherweight title when Linares relinquished it to move up in weight.

He won his first defense of his title with a split decision win over Takahiro Ao on October 16, 2008. Despite being floored in the 4th round, Larios managed to outbox the Japanese challenger for the victory.^[3]

The two fighters met again on March 12, 2009. Like in the previous encounter, the matches resulted in a decision. But this time, it was in Aoh's favor.