William Henry McKeighan (July 1, 1886 – September 15, 1957) was a Michigan politician and state political boss based in Flint.^[1] Together with Detroit Mayor Ed Barnard and Grand Rapids politician-businessman Frank D. McKay form a Republican political triumvirate with ties to the Purple Gang of Detroit.^[2]

William H. McKeighan was born in 1886 in Cleveland. In Saginaw, he attended high school. He moved to Flint in 1908, initially working in a drug store. A year later, he opened his own pharmacy. McKeighan established a "base of operations at Leith Street and Industrial Avenue" where he owned a barber shop and pool hall, then organized his political machine.^[2]

McKeighan in 1913 was elected as a Flint city alderman at age 27.^[2] He was elected five times to the office of Mayor of City of Flint. His first time was in 1915 for a single 1-year term then again in 1922^[3] defeating Marvin C. Barney, Citizens Party candidate. On April 3, 1923, he was defeated in the race for mayor by David R. Cuthbertson.^[1] He was elected as mayor again in 1927. A recall election to remove McKeighan in 1927 failed during which the police arrested recall supporters. In 1928, he faced conspiracy charges.^[4]

McKeighan was under investigation for a multitude of crimes and ticked off the rest of the city leaders that they pushed for changes in the city charter to a council-manager form with the council called commission. So, he ran the "Green Slate" of candidates who won in 1931 and 1932 that^[2] he was selected Flint Mayor in 1931 by the other City Commissioners. He entered the 1932 primary Governor of Michigan race. In 1940, he was a delegate to the Republican National Convention from Michigan. Along with his political ally, Frank D. McKay, McKeighan was charged with conspiracy to violate state liquor laws in 1945; he was given a judge-directed verdict of not guilty.^[3]