WNT2B

WNT2B

WNT2B

Protein-coding gene in the species Homo sapiens

Protein Wnt-2b (formerly Wnt13[5]) is a protein that in humans is encoded by the WNT2B gene.[6][7][8]

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This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as human carcinogenesis. This gene produces two alternative transcript variants.[8]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000134245 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000027840 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Kubo F, Takeichi M, Nakagawa S (2003). "Wnt2b controls retinal cell differentiation at the ciliary marginal zone". Development. 130 (3): 587–98. doi:10.1242/dev.00244. PMID 12490564. S2CID 6642249.
  6. [6]
    Katoh M, Hirai M, Sugimura T, Terada M (Oct 1996). "Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family". Oncogene. 13 (4): 873–6. PMID 8761309.
  7. [7]
    Katoh M, Kirikoshi H, Saitoh T, Sagara N, Koike J (Sep 2000). "Alternative splicing of the WNT-2B/WNT-13 gene". Biochem Biophys Res Commun. 275 (1): 209–16. doi:10.1006/bbrc.2000.3252. PMID 10944466.
  8. [8]
    "Entrez Gene: WNT2B wingless-type MMTV integration site family, member 2B".

Further reading



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