WNT10B

WNT10B

WNT10B

Protein-coding gene in the species Homo sapiens

Protein Wnt-10b (formerly Wnt12[5]) is a protein that in humans is encoded by the WNT10B gene.[6][7][8][9]

Quick Facts Identifiers, Aliases ...

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis.

This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is, it is presumed, a molecular switch that governs adipogenesis. Gain-of-function of Wnt10b in mouse hearts has shown to improve cardiac tissue repair after myocardial injury, by promoting coronary vessel formation and attenuating pathological fibrosis.[10] This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region.[9]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000169884 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000022996 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Schubert M, Holland LZ, Holland ND, Jacobs DK (2000). "A phylogenetic tree of the Wnt genes based on all available full-length sequences, including five from the cephalochordate amphioxus". Molecular Biology and Evolution. 17 (12): 1896–903. doi:10.1093/oxfordjournals.molbev.a026291. PMID 11110906.
  6. [6]
    Bui TD, Rankin J, Smith K, Huguet EL, Ruben S, Strachan T, Harris AL, Lindsay S (Apr 1997). "A novel human Wnt gene, WNT10B, maps to 12q13 and is expressed in human breast carcinomas". Oncogene. 14 (10): 1249–53. doi:10.1038/sj.onc.1200936. PMID 9121776.
  7. [7]
    Hardiman G, Kastelein RA, Bazan JF (Sep 1997). "Isolation, characterization and chromosomal localization of human WNT10B". Cytogenet Cell Genet. 77 (3–4): 278–82. doi:10.1159/000134597. PMID 9284937.
  8. [8]
    Ugur SA, Tolun A (Aug 2008). "Homozygous WNT10b mutation and complex inheritance in Split-Hand/Foot Malformation". Hum Mol Genet. 17 (17): 2644–53. doi:10.1093/hmg/ddn164. PMID 18515319.
  9. [9]
    "Entrez Gene: WNT10B wingless-type MMTV integration site family, member 10B".
  10. [10]
    Paik DT, Rai M, Ryzhov S, Sanders LN, Aisagbonhi O, Funke MJ, Feoktistov I, Hatzopoulos AK. Wnt10b gain-of-function improves cardiac repair by arteriole formation and attenuation of fibrosis. Circ Res. 2015; 117:804-816.

Further reading



Stub icon

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.
Share this article:

This article uses material from the Wikipedia article WNT10B, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.