WB-4101
WB-4101
Chemical compound
WB-4101 is a compound which acts as an antagonist at the α1B-adrenergic receptor. It was one of the first selective antagonists developed for this receptor and was invented in 1969, but is still commonly used in research into adrenergic receptors, especially as a lead compound from which to develop more selective drugs.[1][2][3][4][5][6]
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Formula | C19H23NO5 |
Molar mass | 345.395 g·mol−1 |
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- Green PN, Shapero M, Wilson C (March 1969). "The synthesis and pharmacological properties of a series of 2-substituted aminomethyl-1,4-benzodioxanes". Journal of Medicinal Chemistry. 12 (2): 326–9. doi:10.1021/jm00302a033. PMID 5791620.
- Melchiorre C, Bolognesi ML, Budriesi R, Chiarini A, Giardinà D, Minarini A, et al. (April 1998). "Search for selective antagonists at alpha 1-adrenoreceptors: neutral or negative antagonism?". Farmaco. 53 (4): 278–86. doi:10.1016/S0014-827X(98)00022-6. PMID 9658586.
- Melchiorre C, Angeli P, Bolognesi ML, Chiarini A, Giardinà D, Gulini U, et al. (March 2000). "Alpha 1-adrenoreceptor antagonists bearing a quinazoline or a benzodioxane moiety". Pharmaceutica Acta Helvetiae. 74 (2–3): 181–90. doi:10.1016/S0031-6865(99)00049-7. PMID 10812956.
- Fumagalli L, Pallavicini M, Budriesi R, Gobbi M, Straniero V, Zagami M, et al. (December 2012). "Affinity and activity profiling of unichiral 8-substituted 1,4-benzodioxane analogues of WB4101 reveals a potent and selective α1B-adrenoceptor antagonist". European Journal of Medicinal Chemistry. 58: 184–91. doi:10.1016/j.ejmech.2012.09.049. PMID 23124215.
- Fumagalli L, Pallavicini M, Budriesi R, Bolchi C, Canovi M, Chiarini A, et al. (August 2013). "6-methoxy-7-benzofuranoxy and 6-methoxy-7-indolyloxy analogues of 2-[2-(2,6-Dimethoxyphenoxy)ethyl]aminomethyl-1,4-benzodioxane (WB4101):1 discovery of a potent and selective α1D-adrenoceptor antagonist". Journal of Medicinal Chemistry. 56 (16): 6402–12. doi:10.1021/jm400867d. PMID 23902232.
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