Vibriobactin

Vibriobactin

Vibriobactin

Chemical compound

Vibriobactin is a catechol siderophore that helps the microbial system to acquire iron. It was first isolated from Vibrio cholerae.[1]

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Structure and biosynthesis

The components of vibriobactin are three 2,3-dihydroxybenzoic acid (DHB), two threonine (Thr), and one norspermidine (NSPD). DHB is synthesized from chorismic acid by a series of enzymes: VibA, VibB, and VibC. DHB is linked to NSPD by VibE, VibB and VibH in order and forms DHB-NSPD.[2] On the other hand, DHB performs condensation and cyclization with Thr by VibE, VibB, and VibF to form the heterocyclic molecule linked on VibF: DHB-Thr-VibF. DHB-NSPD and DHB-Thr-VibF are then put together by VibF to form vibriobactin.[3]

References

  1. [1]
    Griffiths, Gary L.; Sigel, Suzanne P.; Payne, Shelley M.; Neilands, J. B. (1984). "Vibriobactin, a Siderophore from Vibrio cholerae". The Journal of Biological Chemistry. 259 (1): 383–385. doi:10.1016/S0021-9258(17)43671-4. PMID 6706943.
  2. [2]
    Keating, Thomas A.; Marshall, C. Gary; Walsh, Christopher T. (2000). "Vibriobactin Biosynthesis in Vibrio cholerae: VibH Is an Amide Synthase Homologous to Nonribosomal Peptide Synthetase Condensation Domains". Biochemistry. 39 (50): 15514. doi:10.1021/bi001651a. PMID 11112537.
  3. [3]
    Marshall, C. Gary; Burkart, Michael D.; Keating, Thomas A.; Walsh, Christopher T. (2001). "Heterocycle Formation in Vibriobactin Biosynthesis: Alternative Substrate Utilization and Identification of a Condensed Intermediate". Biochemistry. 40 (35): 10656. doi:10.1021/bi010937s. PMID 11524010.
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