Very-long-chain_3-oxoacyl-CoA_reductase

Very-long-chain 3-oxoacyl-CoA reductase

Very-long-chain 3-oxoacyl-CoA reductase

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Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330, very-long-chain 3-ketoacyl-CoA reductase, very-long-chain beta-ketoacyl-CoA reductase, KCR (gene), IFA38 (gene)) is an enzyme with systematic name (3R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction

a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP+ a very-long-chain 3-oxoacyl-CoA + NADPH + H+
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This microsomal complex extends palmitoyl-CoA and stearoyl-CoA (and their modified forms) to very-long-chain acyl CoAs.

References

  1. [1]
    Beaudoin F, Gable K, Sayanova O, Dunn T, Napier JA (March 2002). "A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase". The Journal of Biological Chemistry. 277 (13): 11481–8. doi:10.1074/jbc.M111441200. PMID 11792704.
  2. [2]
    Han G, Gable K, Kohlwein SD, Beaudoin F, Napier JA, Dunn TM (September 2002). "The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase". The Journal of Biological Chemistry. 277 (38): 35440–9. doi:10.1074/jbc.M205620200. PMID 12087109.
  3. [3]
    Beaudoin F, Wu X, Li F, Haslam RP, Markham JE, Zheng H, Napier JA, Kunst L (July 2009). "Functional characterization of the Arabidopsis beta-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase". Plant Physiology. 150 (3): 1174–91. doi:10.1104/pp.109.137497. PMC 2705042. PMID 19439572.
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