Vapreotide

Vapreotide
Clinical data
Trade names	Sanvar
Other names	H-D-Phe-Cys(1)-Tyr-D-Trp-Lys-Val-Cys(1)-Trp-NH2; Octastatin
ATC code	H01CB04 (WHO) ;
Pharmacokinetic data
Elimination half-life	30 minutes
Identifiers
	IUPAC name D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-L-tryptophanamide (2->7)-disulfide;
CAS Number	103222-11-3;
PubChem CID	23725064;
PubChem SID	46506923;
DrugBank	DB04894;
ChemSpider	64425;
UNII	2PK59M9GFF;
KEGG	D06281;
CompTox Dashboard (EPA)	DTXSID00883113 ;
Chemical and physical data
Formula	C57H70N12O9S2
Molar mass	1131.38 g·mol−1
3D model (JSmol)	Interactive image;
Density	1.4 g/cm3
Boiling point	1,540.9 °C (2,805.6 °F)
	SMILES CC(C)[C@H]1C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N1)CCCCN)Cc2c[nH]c3c2cccc3)Cc4ccc(cc4)O)NC(=O)[C@@H](Cc5ccccc5)N)C(=O)N[C@@H](Cc6c[nH]c7c6cccc7)C(=O)N;
	InChI InChI=1S/C57H70N12O9S2/c1-32(2)49-57(78)68-48(55(76)64-44(50(60)71)26-35-28-61-41-16-8-6-14-38(35)41)31-80-79-30-47(67-51(72)40(59)24-33-12-4-3-5-13-33)56(77)65-45(25-34-19-21-37(70)22-20-34)53(74)66-46(27-36-29-62-42-17-9-7-15-39(36)42)54(75)63-43(52(73)69-49)18-10-11-23-58/h3-9,12-17,19-22,28-29,32,40,43-49,61-62,70H,10-11,18,23-27,30-31,58-59H2,1-2H3,(H2,60,71)(H,63,75)(H,64,76)(H,65,77)(H,66,74)(H,67,72)(H,68,78)(H,69,73)/t40-,43+,44+,45+,46-,47+,48+,49+/m1/s1; Key:SWXOGPJRIDTIRL-DOUNNPEJSA-N;

Vapreotide

Pharmaceutical drug

Vapreotide (Sanvar) is a synthetic somatostatin analog. It is used in the treatment of esophageal variceal bleeding^[1]^[2] in patients with cirrhotic liver disease and AIDS-related diarrhea.^[3]

Quick Facts Clinical data, Trade names ...

It is an 8 residue peptide with sequence H-D-Phe-Cys(1)-Tyr-D-Trp-Lys-Val-Cys(1)-Trp-NH2.

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This article uses material from the Wikipedia article Vapreotide, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.

[pmid19072353-1] [1]
Calès P (April 2008). "Vapreotide acetate for the treatment of esophageal variceal bleeding". Expert Review of Gastroenterology & Hepatology. 2 (2): 185–92. doi:10.1586/17474124.2.2.185. PMID 19072353. S2CID 2681639.

[pmid19708854-2] [2]
Fortune BE, Jackson J, Leonard J, Trotter JF (October 2009). "Vapreotide: a somatostatin analog for the treatment of acute variceal bleeding". Expert Opinion on Pharmacotherapy. 10 (14): 2337–42. doi:10.1517/14656560903207019. PMID 19708854. S2CID 24475861.

[DrugBank-3] [3]
DrugBank DB04894

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[2]

[3]

Vapreotide

References

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