Uroguanylin

Uroguanylin

Uroguanylin

Chemical compound

Uroguanylin is a 16 amino acid peptide that is secreted by enterochromaffin cells in the duodenum and proximal small intestine. Guanylin acts as an agonist of the guanylyl cyclase receptor guanylate cyclase 2C (GC-C), and regulates electrolyte and water transport in intestinal and renal epithelia. By agonizing this guanylyl cyclase receptor, uroguanylin and guanylin cause intestinal secretion of chloride and bicarbonate to dramatically increase; this process is helped by the second messenger cGMP.[1] Its sequence is H-Asn-Asp-Asp-Cys(1)-Glu-Leu-Cys(2)-Val-Asn-Val-Ala-Cys(1)-Thr-Gly-Cys(2)-Leu-OH.

Quick Facts guanylate cyclase activator 2B (uroguanylin), Identifiers ...
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In humans, the uroguanylin peptide is encoded by the GUCA2B gene.[2][3] Uroguanylin may be involved in appetite and perceptions of 'fullness' after eating meals, as suggested by a study into mice.[4]

See also

References

  1. [1]
    Forte, Leonard Ralph (1 November 2004). "Uroguanylin and guanylin peptides: pharmacology and experimental therapeutics". Pharmacology & Therapeutics. 104 (2): 137–162. doi:10.1016/j.pharmthera.2004.08.007. PMID 15518884. Retrieved 16 January 2023.
  2. [2]
    Miyazato M, Nakazato M, Yamaguchi H, Date Y, Kojima M, Kangawa K, Matsuo H, Matsukura S (February 1996). "Cloning and characterization of a cDNA encoding a precursor for human uroguanylin". Biochemical and Biophysical Research Communications. 219 (2): 644–8. doi:10.1006/bbrc.1996.0287. PMID 8605041.
  3. [3]
    Miyazato M, Nakazato M, Matsukura S, Kangawa K, Matsuo H (August 1997). "Genomic structure and chromosomal localization of human uroguanylin". Genomics. 43 (3): 359–65. doi:10.1006/geno.1997.4808. PMID 9268639.
  4. [4]
    Rahbi H, Narayan H, Jones DJ, Ng LL (December 2012). "The uroguanylin system and human disease". Clinical Science. 123 (12): 659–68. doi:10.1042/CS20120021. PMID 22877138. S2CID 16444915.
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