U-48800

U-48800

U-48800

Chemical compound

U-48800 is an opioid analgesic which has been sold as a designer drug. Unlike U-47700, it is primarily active as a kappa opioid receptor agonist with only moderate affinity at the mu opioid receptor. Nevertheless, it has still appeared on the recreational drug market, often as a component of combinations with other drugs, and has been linked to numerous drug overdose cases.[1][2][3][4][5]

Quick Facts Identifiers, CAS Number ...


See also

References

  1. [1]
    Gampfer TM, Richter LH, Schäper J, Wagmann L, Meyer MR (October 2019). "Toxicokinetics and analytical toxicology of the abused opioid U-48800 - in vitro metabolism, metabolic stability, isozyme mapping, and plasma protein binding". Drug Testing and Analysis. 11 (10): 1572–1580. doi:10.1002/dta.2683. PMID 31424163.
  2. [2]
    Baumann MH, Tocco G, Papsun DM, Mohr AL, Fogarty MF, Krotulski AJ (November 2020). "U-47700 and Its Analogs: Non-Fentanyl Synthetic Opioids Impacting the Recreational Drug Market". Brain Sciences. 10 (11): 895. doi:10.3390/brainsci10110895. PMC 7700279. PMID 33238449.
  3. [3]
    Fogarty MF, Mohr AL, Papsun DM, Logan BK (February 2022). "Analysis of the Illicit Opioid U-48800 and Related Compounds by LC-MS-MS and Case Series of Fatalities Involving U-48800". Journal of Analytical Toxicology. 46 (1): 17–24. doi:10.1093/jat/bkaa180. PMID 33237987.
  4. [4]
    Otte L, Wilde M, Auwärter V, Grafinger KE (July 2022). "Investigation of the μ- and κ-opioid receptor activation by eight new synthetic opioids using the [35 S]-GTPγS assay: U-47700, isopropyl U-47700, U-49900, U-47931E, N-methyl U-47931E, U-51754, U-48520, and U-48800". Drug Testing and Analysis. 14 (7): 1187–1199. doi:10.1002/dta.3238. PMID 35142070.
  5. [5]
    Amend N, Thiermann H, Worek F, Wille T (June 2023). "A pharmacologically pre-contracted smooth muscle bowel model for the study of highly-potent opioid receptor agonists and antagonists". Toxicology Letters. 382: 41–46. doi:10.1016/j.toxlet.2023.05.010. PMID 37245850.



Stub icon

This analgesic-related article is a stub. You can help Wikipedia by expanding it.
Share this article:

This article uses material from the Wikipedia article U-48800, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.