The trigeminal lemniscus, also called the trigeminothalamic tract, is composed of the ventral trigeminal tract, and the dorsal trigeminal tract – nerve tracts that convey tactile, pain, and temperature impulses from the skin of the face, the mucous membranes of the nasal and oral cavities, and the eye, as well as proprioceptive information from the facial and masticatory muscles.

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The trigeminal lemniscus is composed of second order neuronal axons in the brainstem. It carries sensory information from the trigeminal system to the ventral posteromedial (VPM) nucleus of the thalamus.

This tract was historically considered a cephalic division of the medial lemniscus due to the close proximity of the two ascending tracts.^[1] Like the medial lemniscus in the dorsal column-medial lemniscus pathway (DCML), that carries mechanosensory information from part of the head and the rest of the body, the trigeminal lemniscus carries mechanosensory information from the face.^[2] However, the trigeminal lemniscus also carries pain and temperature sensations from the contralateral orofacial region, just as the spinothalamic tract carries these sensations from the contralateral body. Thus, the trigeminal lemniscus of the head is functionally analogous to both the DCML tracts and the spinothalamic tract of the body.

The trigeminal lemniscus contains two main divisions:

• The ventral trigeminal tract, consisting of second order neuronal axons from the Spinal Nucleus of Trigeminal nerve. These fibers cross the midline and ascend to the contralateral thalamus.
• The dorsal trigeminal tract, consisting of second order neuronal axons from the principal (chief sensory) nucleus. These fibers do not cross the midline, and ascend to the ipsilateral thalamus.