2009-2010: Breakthrough

On the silver screen, Tisha first appeared in Mostofa Sarwar Farooki's critically acclaimed Third Person Singular Number in 2009 starring alongside Mosharraf Karim, Topu, Abul Hayat and others. Jay Weissberg of Variety stated that, "Ruba's revulsion, yet lack of surprise, is beautifully calibrated by Tisha".^[14] For her role Ruba Haque, she was nominated for the Best Film Actress and won the Critics Choice Award for Best Film Actress in the 12th Meril-Prothom Alo Awards.^[15] The film was the Bangladeshi submissions for the 83rd Academy Awards for Best International Feature Film. Following year, she made a special appearance as Selina in the film Runway directed by Tareque Masud.

2012–2016: Television and other success

Following the success of Third Person Singular Number, in 2012 she starred in Television alongside Chanchal Chowdhury and Mosharraf Karim and directed by Farooki. For her role Kohinur, she was nominated for the Meril-Prothom Alo Award for Best Film Actress. The film also was the Bangladeshi submissions for the 86th Academy Awards for Best International Feature Film.

In 2016, she did her first commercial movie Rana Pagla: The Mental opposite superstar Shakib Khan directed by Shamim Ahmed Roni. Later in the year, she appeared in Ostitto directed by Anonno Mamun starring opposite Arifin Shuvo. For her outstanding performance in this film, she was honoured with the Bangladesh National Film Award for Best Actress in 2016^[16] and nominated for the Meril-Prothom Alo Award for Best Film Actress.

2017-present

In 2017, she was seen in Doob, a Bangladesh-India co-production directed by Mostofa Sarwar Farooki starring alongside Irrfan Khan, Parno Mittra and Rokeya Prachy. She received the prestigious Meril-Prothom Alo Award for Best Film Actress for her performance. The film was the Bangladeshi submissions for the 91st Academy Awards for Best International Feature Film.^[17][18] Later she was seen in Haldaa directed by Tauquir Ahmed starring along with Mosharraf Karim, Zahid Hasan and others. She received her second Bangladesh National Film Award for Best Actress for her role in this film^[19] along with Bachsas Award for Best Actress category. In 2018, she starred in the first anthology film of Bangladesh Iti, Tomari Dhaka.

Her first release of 2019 was Fagun Haway based on the historic Language movement of 1952 directed by Tauquir Ahmed starring Siam Ahmed, Abul Hayat, Yashpal Sharma and others. The film was the Bangladeshi submissions for the 92nd Academy Awards for Best International Feature Film. In the same year, she starred as Toru for short The Old Man and The Girl by Afzal Hossain Munna. Tisha is seen in the much anticipated Bangladesh-Germany-Russia co-production Shonibar Bikel directed by Farooki starring along with a multicultural cast including Zahid Hasan, Mamunur Rashid, Parambrata Chatterjee, Eyad Hourani. It is a one-shot thriller inspired by the Holey Artisan Bakery attack in 2016. In this year she also starred in Mayaboti alongside Yash Rohan directed by Arun Chowdhury and featuring in Bonhi a short by Afsana Mimi.^[20] She also appeared in Holudboni, a Bangladesh-India co-production alongside Parambrata Chatterjee and Paoli Dam directed by Mukul Roy Chowdhury and Taher Shipon.

Tisha will soon debut as a co-producer in No Land's Man starring Nawazuddin Siddiqui and directed by Mostofa Sarwar Farooki.^[21][22] She also co-producer upcoming film A Burning Question directed by Farooki.^[23] As of 2020, she would play the role of Sheikh Fazilatunnesa Mujib in the upcoming film Bangabandhu, based on the life of Sheikh Mujibur Rahman, directed by Shyam Benegal.^[24] She also would play the valiant revolutionary Pritilata Waddedar opposite Manoj Kumar in the film Bhalobasha Pritilata directed and co-produced by Pradip Ghosh.^[25][26] She will appear films Dhaka 2040, Bobaa Rohossho by Abhishek Bagchi^[27][28] and Balighar in the upcoming years.