Tiflorex
Tiflorex
Never marketed appetite suppressant
Tiflorex (TFX), formerly known as flutiorex, is a stimulant[citation needed] amphetamine that was under development as an appetite suppressant in the 1970s,[1][2] but appears to have been abandoned. It is structurally related to fenfluramine and 4-MTA.
Tiflorex went to phase II clinical trials. The extended release formulation "TFX-SR" produced significant suppression of appetite. It also caused slightly more sleep disturbances and headaches than placebo, as well as mydriasis and a self-reported decrease in arousal. It had little effect on heart rate.[2]
Tifluorex is claimed to be a more potent anorectic than fenfluramine, with twice its potency in humans[2] and 4 times its potency in rats.[3]