The Thomas More Saints are the athletic teams that represent Thomas More University, located in Crestview Hills, Kentucky, in National Collegiate Athletic Association (NCAA) intercollegiate sports. The Saints are currently transitionary members of the NCAA's Division II as they move all varsity sports from the Mid-South Conference of the National Association of Intercollegiate Athletics to the NCAA Great Midwest Athletic Conference The university will compete in the Great Midwest and be eligible for conference championships and tournaments beginning in the 2023–24 academic year, and, following the mandatory transition period, TMU teams will be eligible for NCAA Championships during the 2025-26 year.

Thomas More announced its transition to NCAA Division II athletics in July 2022. The Saints had been in the NAIA for the past two academic years and will retain NAIA membership until completion of the 2022–23 academic year. The Saints previously competed as a member of the Division III ranks of the National Collegiate Athletic Association (NCAA), primarily competing in the short-lived American Collegiate Athletic Association (ACAA) during only the 2018–19 school year; as well as a member of the Presidents' Athletic Conference (PAC) from 2005–06 to 2017–18.

Thomas More had previously been members of the NAIA from 1947–48 to 1989–90.^[2]

Thomas More University and the Florence Y’alls Baseball Club partnered in March 2022 to rename the home of the Florence Y’alls “Thomas More Stadium.” As part of the agreement, the stadium will also become the home of the Thomas More Saints’ baseball team starting in spring 2023. Thomas More announced a major comprehensive fundraising campaign in Fall 2021 in support of a five-year strategic plan that includes enhanced athletic facilities for many of the Saints 29 sports teams. Additional plans are in place for other facility upgrades at the university that will affect additional Saints sports teams positively; renovations at Republic Bank Field and its track were completed in 2021.