Thebaine_6-O-demethylase

Thebaine 6-O-demethylase

Thebaine 6-O-demethylase

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Thebaine 6-O-demethylase (EC 1.14.11.31, T6ODM) is an enzyme with systematic name thebaine,2-oxoglutarate:oxygen oxidoreductase (6-O-demethylating).[1] This enzyme catalyses the following chemical reaction

thebaine + 2-oxoglutarate + O2 neopinone + formaldehyde + succinate + CO2
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Thebaine 6-O-demethylase contains Fe2+.

References

  1. [1]
    Hagel JM, Facchini PJ (April 2010). "Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy". Nature Chemical Biology. 6 (4): 273–5. doi:10.1038/nchembio.317. PMID 20228795.
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