Template:Potencies_and_durations_of_natural_estrogens_by_intramuscular_injection

Template:Potencies and durations of natural estrogens by intramuscular injection

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Howard ME (1949). Modern Drug Encyclopedia and Therapeutic Index. Drug Publications. p. 322. Supply: ALPHA ESTRADIOL, U.S.P. IN SESAME OIL—For intramuscular injection, 0.14 mg per cc, 0.28 mg per cc, and 0.7 mg per cc. Ampuls—1 cc—Boxes of 12, 25, 100. Vials, 30 cc—Boxes of 1, 6. (Chicago Pharmacal). ALPHA-ESTRADIOL, U.S.P. IN SUSPENSION—0.14 mg per cc, 0.28 mg per cc, and 0.7 mg per cc. Vials, 30 cc—Boxes of 1, 6. (Chicago Pharmacal).

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Osol A, Pratt R (1973). The United States dispensatory. Lippincott. p. 498. ISBN 978-0-397-55901-5. The following dosages for estradiol in the form of aqueous suspension injected intramuscularly, or pellets implanted subcutaneously, are recommended by a leading maunfacturer: Menopausal syndrome.—In average cases, 1 mg. intramuscularly 2 or 3 times weekly for 2 or 3 weeks; in more severe cases, 1 to 1.5 mg. Thereafter dosage is reduced to the minimum requirement, usually within the range of 0.5 to 1 mg. of estradiol twice weekly.

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Kaiser R (September 1961). "[Estrogen excretion during the cycle and after injection of estradiol esters. A contribution to therapy with depot estrogens]" [Estrogen excretion during the cycle and after injection of estradiol esters. A contribution to therapy with depot estrogens]. Geburtshilfe und Frauenheilkunde (in German). 21: 868–878. PMID 13750804.

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Kaiser R (1962). "Über die Oestrogenausscheidung nach Injektion von Oestradiolestern" [Estrogen excretion after injection of estradiol esters]. Gewebs-und Neurohormone: Physiologie des Melanophorenhormons [Tissue and Neurohormones: Physiology of the Melanophore Hormone] (in German). Springer, Berlin, Heidelberg. pp. 227–232. doi:10.1007/978-3-642-86860-3_24. ISBN 978-3-540-02909-0.

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Ferin J (January 1952). "Relative duration of action of natural and synthetic estrogens administered parenterally in women with estrogen deficiency". The Journal of Clinical Endocrinology and Metabolism. 12 (1): 28–35. doi:10.1210/jcem-12-1-28. PMID 14907837.

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Wiemeyer JC, Fernandez M, Moguilevsky JA, Sagasta CL (November 1986). "Pharmacokinetic studies of estradiol enantate in menopausic women". Arzneimittel-Forschung. 36 (11): 1674–1677. PMID 3814225.

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Wied GL (January 1954). "[Estradiol valerate and estradiol undecylate, two new estrogens with prolonged action; comparison with estradiol benzoate]" [Estradiol valerate and estradiol undecylate, two new estrogens with prolonged action; comparison with estradiol benzoate]. Geburtshilfe und Frauenheilkunde (in German). 14 (1): 45–52. PMID 13142295.

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Gouygou C, Gueritee N, Pye A (1956). "[A fat-soluble, delayed estrogen : the estradiol undecylate]" [A fat-soluble, delayed estrogen: the estradiol undecylate]. Therapie (in French). 11 (5): 909–917. PMID 13391788.

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Micromedex (1 January 2003). USP DI 2003: Drug Information for Healthcare Professionals. Thomson Micromedex. p. 1246. ISBN 978-1-56363-429-1. ESTRONE Parenteral Dosage Forms ESTRONE INJECTABLE SUSPENSION USP Usual adult dose Atrophic vaginitis or Menopausal (vasomotor) symptoms or Vulvar atrophy—Intramuscular, 100 to 500 mcg (0.1 to 0.5 mg) two or three times a week, cyclically or continuously as appropriate. Estrogen deficiency, due to ovariectomy or Female hypogonadism or Primary ovarian failure—Intramuscular, 100 mcg (0.1 mg) to 1 mg a week, administered as a single dose or in divided doses, cyclically or continuously. A few patients may need doses of up to 2 mg a week.

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Estrogen	Form	EPD	CICD	Duration by dose (mg)
Estrogen	Form	Dose (mg)		Duration by dose (mg)	rowspan="2" \| Refs
Estradiol	Aq. soln.	?	–	<1 d	^[1]
	Oil soln.	40–60	–	1–2 ≈ 1–2 d	^[2]^[3]
	Aq. susp.	?	3.5	0.5–2 ≈ 2–7 d; 3.5 ≈ >5 d	^[2]^[4]^[5]^[6]^[7]
	Microsph.	?	–	1 ≈ 30 d	^[8]^[9]
Estradiol benzoate	Oil soln.	25–35	–	1.66 ≈ 2–3 d; 5 ≈ 3–6 d	^[10]^[11]
	Aq. susp.	20	–	10 ≈ 16–21 d	^[12]^[13]^[14]
	Emulsion	?	–	10 ≈ 14–21 d	^[14]^[15]
Estradiol dipropionate	Oil soln.	25–30	–	5 ≈ 5–8 d	^[10]
Estradiol valerate	Oil soln.	20–30	5	5 ≈ 7–8 d; 10 ≈ 10–14 d; 40 ≈ 14–21 d; 100 ≈ 21–28 d	^[11]^[16]
Estradiol benz. butyrate	Oil soln.	?	10	10 ≈ 21 d	^[17]^[18]
Estradiol cypionate	Oil soln.	20–30	–	5 ≈ 11–14 d	^[11]
Estradiol cypionate	Aq. susp.	?	5	5 ≈ 14–24 d	^[19]^[20]^[21]
Estradiol enanthate	Oil soln.	?	5–10	10 ≈ 20–30 d	^[22]^[23]^[24]
Estradiol dienanthate	Oil soln.	?	–	7.5 ≈ >40 d	^[25]^[26]
Estradiol undecylate	Oil soln.	?	–	10–20 ≈ 40–60 d; 25–50 ≈ 60–120 d	^[27]^[28]
Polyestradiol phosphate	Aq. soln.	40–60	–	40 ≈ 30 d; 80 ≈ 60 d; 160 ≈ 120 d	^[29]^[30]
Estrone	Oil soln.	?	–	1–2 ≈ 2–3 d	^[3]^[31]
Estrone	Aq. susp.	?	–	0.1–2 ≈ 2–7 d	^[32]
Estriol	Oil soln.	?	–	1–2 ≈ 1–4 d	^[3]^[33]
Polyestriol phosphate	Aq. soln.	?	–	50 ≈ 30 d; 80 ≈ 60 d
Notes and sources Notes: All aqueous suspensions are of microcrystalline particle size. Estradiol production during the menstrual cycle is 30–640 µg/d (6.4–8.6 mg total per month or cycle). The vaginal epithelium maturation dosage of estradiol benzoate or estradiol valerate has been reported as 5 to 7 mg/week. An effective ovulation-inhibiting dose of estradiol undecylate is 20–30 mg/month. Sources: Main/General: ^[34]^[35]^[36]^[37]^[38]^[39]^[40]^[41]^[42] Miscellaneous: ^[43]^[44]^[45]

Template:Potencies_and_durations_of_natural_estrogens_by_intramuscular_injection

Template:Potencies and durations of natural estrogens by intramuscular injection

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