Template:Plasma_estrogen_levels_after_a_single_dose_of_conjugated_estrogens_by_different_routes
Template:Plasma estrogen levels after a single dose of conjugated estrogens by different routes
More information Route, Dose ...
| Route | Dose | Time | E2 (↑Δ) | E1 (↑Δ) | Ratio | ! Ref |
|---|---|---|---|---|---|---|
| Oral | 0.3 mg 0.625 mg 1.25 mg 1.25 mg 2.5 mg | 6 hours 6 hours 6 hours 1 hour 6 hours | +20 pg/mL +50 pg/mL +70 pg/mL +35–58 pg/mL +160 pg/mL | ND ND ND 110 pg/mL ND | ND ND ND 0.32–0.52 ND | [1] [1] [1] [2] [1] |
| Vaginal (cream) | 0.3 mg 0.625 mg 0.625 mg 1.25 mg 1.25 mg 2.5 mg | ND ND ND 2 hours ND ND | +4 pg/mL +13–29 pg/mL +17 pg/mL +25 pg/mL +27 pg/mL +32 pg/mL | +20 pg/mL +29–55 pg/mL +45 pg/mL +50 pg/mL +110 pg/mL +40 pg/mL | 0.2 0.24–1.0 0.38 0.5 0.25 0.8 | [3] [4] [3] [5] [3] [3] |
| Intravenousa | 20 mg | 5 min 30 min 60 min 120 min | 800 pg/mL 3000 pg/mL 3500 pg/mL 3100 pg/mL | 4500 pg/mL 24000 pg/mL 19000 pg/mL 10500 pg/mL | 1:5.3 1:8.1 1:5.5 1:3.4 | [6] [6] [6] [6] |
| Notes: a = Absolute levels, not change. Sources: [7] | ||||||
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- Nichols KC, Schenkel L, Benson H (1984). "17 beta-estradiol for postmenopausal estrogen replacement therapy". Obstet Gynecol Surv. 39 (4): 230–45. doi:10.1097/00006254-198404000-00022. PMID 6717863.