Tagraxofusp
Tagraxofusp
Pharmaceutical drug
Tagraxofusp, sold under the brand name Elzonris, is an anti-cancer medication for the treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN).[5][6]
Tagraxofusp is a fusion protein consisting of interleukin 3 (IL-3) fused to diphtheria toxin.[7][2] The fusion protein readily kills cultured pDC by binding to their IL-3 receptors to thereby gain entrance to the cells and then blocking these cells' protein synthesis (due to its diphtheria toxin portion inhibiting eukaryotic elongation factor 2).[medical citation needed]
It was approved for use in the United States in 2018,[8] and in the European Union in January 2021.[3] The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication.[9]