TRNA-dihydrouridine47_synthase_(NAD(P)+)

TRNA-dihydrouridine47 synthase (NAD(P)+)

TRNA-dihydrouridine47 synthase (NAD(P)+)

Class of enzymes


TRNA-dihydrouridine47 synthase (NAD(P)+) (EC 1.3.1.89, Dus3p, tRNA-dihydrouridine synthase 3) is an enzyme with systematic name tRNA-5,6-dihydrouracil47:NAD(P)+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction

5,6-dihydrouracil47 in tRNA + NAD(P)+ uracil47 in tRNA + NAD(P)H + H+

This enzyme specifically modifies uracil47 in tRNA.


References

  1. Xing F, Hiley SL, Hughes TR, Phizicky EM (April 2004). "The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs". The Journal of Biological Chemistry. 279 (17): 17850–60. doi:10.1074/jbc.M401221200. PMID 14970222.

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