TRNA-dihydrouridine20_synthase_(NAD(P)+)

TRNA-dihydrouridine20 synthase (NAD(P)+)

TRNA-dihydrouridine20 synthase (NAD(P)+)

Class of enzymes

TRNA-dihydrouridine20 synthase (NAD(P)+) (EC 1.3.1.91, Dus2p, tRNA-dihydrouridine synthase 2) is an enzyme with systematic name tRNA-5,6-dihydrouracil20:NAD(P)+ oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction

5,6-dihydrouracil20 in tRNA + NAD(P)+ uracil20 in tRNA + NAD(P)H + H+
Quick Facts +), Identifiers ...

This enzyme specifically modifies uracil20 in tRNA.

References

  1. [1]
    Xing F, Hiley SL, Hughes TR, Phizicky EM (April 2004). "The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs". The Journal of Biological Chemistry. 279 (17): 17850–60. doi:10.1074/jbc.M401221200. PMID 14970222.
  2. [2]
    Xing F, Martzen MR, Phizicky EM (March 2002). "A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA". RNA. 8 (3): 370–81. doi:10.1017/S1355838202029825. PMC 1370258. PMID 12003496.
  3. [3]
    Rider LW, Ottosen MB, Gattis SG, Palfey BA (April 2009). "Mechanism of dihydrouridine synthase 2 from yeast and the importance of modifications for efficient tRNA reduction". The Journal of Biological Chemistry. 284 (16): 10324–33. doi:10.1074/jbc.M806137200. PMC 2667719. PMID 19139092.
  4. [4]
    Kato T, Daigo Y, Hayama S, Ishikawa N, Yamabuki T, Ito T, Miyamoto M, Kondo S, Nakamura Y (July 2005). "A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis". Cancer Research. 65 (13): 5638–46. doi:10.1158/0008-5472.CAN-05-0600. PMID 15994936.
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