TRAT1

TRAT1
Identifiers
Aliases	TRAT1, TCRIM, TRIM, HSPC062, pp29/30, T cell receptor associated transmembrane adaptor 1, T-cell receptor associated transmembrane adaptor 1
External IDs	OMIM: 604962; MGI: 1924897; HomoloGene: 41130; GeneCards: TRAT1; OMA:TRAT1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	108,855,005 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	48,592,384 bp
RNA expression pattern
	Top expressed in
	lymph node; ; blood; ; appendix; ; thymus; ; spleen; ; gallbladder; ; bone marrow; ; thymus; ; bone marrow cells; ; rectum;
	Top expressed in
	thymus; ; blood; ; spleen; ; subcutaneous adipose tissue; ; superior frontal gyrus; ; vastus lateralis muscle; ; submandibular gland; ; sternocleidomastoid muscle; ; skin of abdomen; ; spermatid;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transmembrane receptor protein tyrosine kinase adaptor activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; T cell receptor complex;
Biological process	positive regulation of calcium-mediated signaling; adaptive immune response; immune system process; positive regulation of T cell receptor signaling pathway; negative regulation of transport; cellular defense response; T cell receptor signaling pathway; negative regulation of receptor recycling; signal transduction; phosphatidylinositol phosphate biosynthetic process; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of protein kinase B signaling;
	Sources:Amigo / QuickGO
Orthologs
	50852
	77647
	ENSG00000163519
	ENSMUSG00000030775
	Q6PIZ9
	Q3UU67
	NM_016388; NM_001317747
	NM_198297
	NP_001304676; NP_057472
	NP_938039
	Wikidata
View/Edit Human	View/Edit Mouse

TRAT1

Protein-coding gene in the species Homo sapiens

T-cell receptor-associated transmembrane adapter 1 is a protein that in humans is encoded by the TRAT1 gene.^[5]^[6]^[7]

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This article uses material from the Wikipedia article TRAT1, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] [1]
GRCh38: Ensembl release 89: ENSG00000163519 – Ensembl, May 2017

[refGRCm38Ensembl-2] [2]
GRCm38: Ensembl release 89: ENSMUSG00000030775 – Ensembl, May 2017

[3] [3]
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] [4]
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10663578-5] [5]
Hubener C, Mincheva A, Lichter P, Schraven B, Bruyns E (Mar 2000). "Genomic organization and chromosomal localization of the human gene encoding the T-cell receptor-interacting molecule (TRIM)". Immunogenetics. 51 (2): 154–8. doi:10.1007/s002510050024. PMID 10663578. S2CID 43325566.

[pmid9687533-6] [6]
Bruyns E, Marie-Cardine A, Kirchgessner H, Sagolla K, Shevchenko A, Mann M, Autschbach F, Bensussan A, Meuer S, Schraven B (Sep 1998). "T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane". J Exp Med. 188 (3): 561–75. doi:10.1084/jem.188.3.561. PMC 2212462. PMID 9687533.

[entrez-7] [7]
"Entrez Gene: TRAT1 T cell receptor associated transmembrane adaptor 1".

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[6]

[7]

[1]

[2]

[3]

[4]

TRAT1

TRAT1

References

Further reading

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