TMIGD1

TMIGD1

TMIGD1

Protein-coding gene in the species Homo sapiens

Transmembrane and immunoglobulin domain containing 1 is a protein that in humans is encoded by the TMIGD1 gene.[5] TMIGD1 was discovered by the lab of Giancarlo Marra[6] and later cloned by Nader Rahimi.[7][8] Recent findings suggest functions in brush border formation (intestinal epithelium) and roles as tumor suppressor (kidney and intestine).[9]

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References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000182271 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000020839 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    "Entrez Gene: Transmembrane and immunoglobulin domain containing 1". Retrieved 2017-02-20.
  6. [6]
    Cattaneo E, Laczko E, Buffoli F, Zorzi F, Bianco MA, Menigatti M, et al. (May 2011). "Preinvasive colorectal lesion transcriptomes correlate with endoscopic morphology (polypoid vs. nonpolypoid)". EMBO Mol Med. 3 (6): 334–347. doi:10.1002/emmm.201100141. PMC 5839393. PMID 3377079.
  7. [7]
    Meyer RD, Zou X, Ali M, Ersoy E, Bondzie PA, Lavaei M, et al. (February 2018). "TMIGD1 acts as a tumor suppressor through regulation of p21Cip1/p27Kip1 in renal cancer". Oncotarget. 9 (11): 9672–9684. doi:10.18632/oncotarget.23822. PMC 5839393. PMID 29515762.
  8. [8]
    Arafa E, Bondzie PA, Rezazadeh K, Meyer RD, Hartsough E, Henderson JM, et al. (October 2015). "TMIGD1 is a novel adhesion molecule that protects epithelial cells from oxidative cell injury". The American Journal of Pathology. 185 (10): 2757–67. doi:10.1016/j.ajpath.2015.06.006. PMC 4607757. PMID 26342724.
  9. [9]
    Thuering E, et al. (April 2023). "TMIGD1: Emerging functions of a tumor suppressor and adhesion receptor". Oncogene. 42 (22): 1777–1785. doi:10.1038/s41388-023-02696-5. PMC 10238269. PMID 37087524.
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