TGIF2

TGIF2

TGIF2

Protein-coding gene in the species Homo sapiens

Homeobox protein TGIF2 is a protein that in humans is encoded by the TGIF2 gene.[5][6]

Quick Facts Identifiers, Aliases ...

The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor. The encoded protein appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and overexpressed in some ovarian cancers, and mutations in this gene can cause holoprosencephaly.[6]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000118707 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000062175 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Imoto I, Pimkhaokham A, Watanabe T, Saito-Ohara F, Soeda E, Inazawa J (Oct 2000). "Amplification and overexpression of TGIF2, a novel homeobox gene of the TALE superclass, in ovarian cancer cell lines". Biochem Biophys Res Commun. 276 (1): 264–70. doi:10.1006/bbrc.2000.3449. PMID 11006116.
  6. [6]
    "Entrez Gene: TGIF2 TGFB-induced factor homeobox 2".

Further reading


Stub icon

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.
Share this article:

This article uses material from the Wikipedia article TGIF2, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.