After a tiring call, the Station 19 crew responds to the car crash into the Emerald City Bar. Inside, Ben and Pruitt team up with Grey Sloan's Jackson, Levi, and Nico to stabilize the injured surgical residents and the couple inside the car. The rest of the crew works from the outside to get everyone out and to the hospital. Tension lingers between Andy and Robert, who has rejected her in favor of impending promotions following Ripley's death. After taking her insubordinate behavior for weeks, he finally orders her to take personal days to stop her from inadvertently influencing the other team members. Maya breaks up with Jack for the same reason. Flashbacks detail the crew celebrating Bailey's pregnancy and being introduced to Jackson as Vic's new boyfriend as well as an explosive fight between Pruitt and his daughter as her sleeping with her Captain threatens to tarnish his legacy.

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This episode begins a crossover event that concludes on Grey's Anatomy season 16 episode 10.

Michael Dixon from the Police Department is promoted as the new Fire Chief. While visiting the best company of the city, he reveals his intent to get the department good publicity. With Andy replaced by Rigo Vasquez from B-shift, the team responds to a call of fireworks going off in a five and dime store. Ben meets a teenager there that reminds him of his younger self as flashbacks detail a joyride accident that left his friend in a permanent vegetative state, which was the reason behind his career choices. Pruitt lets Sullivan know he won't hesitate to inform Dixon of his involvement with Andy if whatever is going on does not stop immediately. Maya reveals to Sullivan she's aiming for Captain if he gets promoted to Battalion Chief while Jack sleeps with Vasquez' wife, only realizing her identity later. Meanwhile, Andy and Ryan babysit her neighbors' kids when she is taken to the hospital after an accident. As Ryan confesses he came back from San Diego because he is still in love with Andy, the young boy appears with his mother's gun and shoots Ryan.

Ryan succumbs to his injury while flashbacks detail his importance in Andy's life throughout the years. Flashbacks also reveal that Pruitt went to visit Ryan in San Diego to ask him to come back and play a role Andy's life given Pruitt's cancer and looming death, further encouraging him to confess his love for her. Andy returns to work soon after the funeral. A disastrous call pushes Ben to advocate for his Physician Response Team. Sullivan seeks out Tom Koracick's help when the pain in his leg becomes increasingly unmanageable. Jackson invites Vic for dinner with his mother, Richard and Maggie and she convinces Dean to come along as a buffer. Jack can't resist sleeping with Rigo's wife again. Pruitt convinces Sullivan not to appoint Andy to Captain as he thinks her state of mind would cause her to blow it, leading to Sullivan recommending Maya for the job.

To move on from his broken relationship, Jack hooks up with the wife of another firefighter. And now that Maya is promoted to captain, it only makes things worse. Like everyone else at Station 19, Jack knows Andy deserved the job. Maya asks the team to abide by the ambulance “patrolling” high-risk areas. Since Miller is late, Maya asks the entire team to repeat the activity. Meanwhile, Ben and Jack mollify a group of homeless foster and biological siblings so they can help save a life and this triggers memories from Jack's past. The new Fire Chief is already creating trouble. Michael Dixon was never a firefighter, he was a former cop and that puts him on a totally different tangent. Jack takes the time to talk to Andy about Ryan's death.

In an effort to increase morale, Maya takes the crew on a team-building camping trip. After a tense night, their bond is put to the test as they work to save first-time campers after a gruesome bear attack. Rigo suspects there is something going on between his wife and Jack when the two arrive late together to help them out. Pruitt and Andy mend their relationship when he offers an apology for his outburst. Sullivan and Ben stay behind from the trip to prepare an aid car for Ben's Physician Response Team. Ben vents his grief about losing his baby while Sullivan steals Fentanyl from the medical supplies. The medication causes him to open up about his personal life and behave erratically, alarming Ben, but Sullivan brushes it off as stress caused by his new job. Maya, feeling isolated and ridiculed by her former friends, flashes back to her youth, when her strict father made her focus on her running career at the cost of a social life.

When a blizzard hits Seattle, the station opens its doors as a shelter for people in the neighborhood, among them is J.J., who goes into labor. Unable to be transported to the hospital, Maya, Andy, and Pruitt help her deliver the baby girl in the station. Maya tries to repair her friendship with Andy. When their argument becomes heated, Maya points out Pruitt's recent hovering over Andy, which leads to Andy piecing together that his cancer is back. She breaks down and is comforted by Robert. Rigo confronts Jack about his sleeping with Eva and beats him up. Jack explains to Dean why he didn't defend himself and Dean judges him for breaking the code amongst firefighters. Ben and Sullivan take care of a man whose foot needs to be amputated, increasing Ben's suspicions of Sullivan's weird behavior. Meanwhile, Travis tries to save a woman with dementia who's snowed in inside of her car in an undisclosed location. As his worried mother checks in on his wellbeing, he thinks back to his parents struggling to accept his sexuality and his breaking off contact with them when they fail to show up for the wedding.

After questioning Maya's ability to be captain Andy decides that she will just stick to the job. Montgomery picks up a guy at bar and in the morning is surprised to discover that he is Chief Dixon's son Emmett, who has been assigned to Station 19 as a rookie. Emmett is slow to get into his turn-out gear and misses the call ending up on desk duty dealing with a homeless man who sneaks in to use the station's showers. The call involves a test rocket that crashed into a gas station igniting a tanker. Gibson tries to stop Vasquez charging at the source of the fire, but he won't listen, and is severely injured when the rocket explodes and he becomes Warren's first patient. Sullivan is still trying to cover up the problem with his leg and ODs on the Fentanyl he stole from Warren's truck. He hallucinates a discussion with Ripley and Emmett finds him passed out on the floor. Warren covers up the missing vials by reporting them as broken in transit.

The team scrambles to save the riders after they respond to a horrific motorbike accident. Sullivan steps up and tries to seek help from Amelia Shepherd (Caterina Scorsone), whose expertise in addiction is of particular interest to him. Dean wonders how to bring up a child on his own, as JJ left. Maya is not messing around on the field and lays into the tough-boss-attitude thick. Dean comes clean to Pruitt about his inexplicable emotions regarding his new daughter, and the lack of confidence he feels about looking after her. Andy finally realizes that Sullivan is her “safe space”. Dean agrees to let Vic move in and they discuss jointly taking care of the baby, who Dean has named "Prue" (Pruitt).

Bishop calls Sullivan and Andy into her office to tell Sullivan that she wants a demotion, thinking that Herrera deserved the promotion instead, which he says he will take under advisement. Dean and Vic adjust to caring for Baby Prue. Jack and Andy are called to an in-progress fight at a gun store, which ends up being between the owner and a troubled veteran who feels he's been robbed by the pawn process. After being disarmed of his knife, he pulls the pin out of a grenade. Flashbacks show Vic as a teen dealing with her grandmother's mental deterioration. Sullivan (ex-Marine) is called to the gun shop to help the suicidal vet, also a former jarhead. Pruitt enlists Ben to help him place dozens of pairs of boots on city hall's steps in protest of the firefighters dying of cancer while not being covered by the city's insurance, embarrassing the new chief, Dixon. Dixon's son, a new recruit and probationary firefighter, admits to Travis that he was an art major and his father pushed him into the academy.

A psychologist visits Station 19 following Rigo's death. Ben opens up about saving Rigo and finally opens up about Bailey's miscarriage and her doubts about him switching from being a doctor to a firefighter. Travis shared about his particularly troubling relationship with his father. Dean lectures Vic that she sabotaged her relationship with Jackson by not telling him that she moved in with Dean. Meanwhile, Andy hasn't been able to come clean with her emotions.

Ben is courting Grey Sloan doctors in order to add a trauma surgeon to his rig. Maya is on vacation with Carina DeLuca but continues to phone the station. Owen Hunt stops by the station to drop a portable ultrasound off to Ben for the mobile unit. Sullivan and Andy travel to have dinner with her father. Chief Dixon stops by the station and introduces Travis, who has been sleeping with new firefighter and Dixon's son Emmett, to Emmett's... girlfriend. Awkward! Dean and Vic are struggling with a colicky Baby Prue until Jack stops by and magically stops her crying. Sullivan stumbles upon the chef of the restaurant berating kitchen employees and threatening to call ICE on them, leading Sullivan to intercede. Teddy Altman visits Ben and loves the idea of doing surgery on wheels, but new motherhood is already too much to deal with. Sullivan compares ICE to Nazis, and says it's personal to him because his grandfather was a Nazi. He springs into action when ICE arrives. Ben entertains Jackson Avery in his surgeon cattle call, and the two of them respond to the bogus injury call that Sullivan makes to help stymie the ICE agents. Everyone's phone lights up with notifications about a 5-alarm fire.

A seemingly simple storage fire became an endangerment to the Station 19 crew due to a dangerous storage of propane gas bottles and poor ventilation, including Andy. Pruitt, hosting a poker game with his old firefighter comrades, leaves the game when he hears about the trouble his handpicked team is in. Arriving at the fire, he puts on the uniform one final time. Inside, Jack and Andy are separated, while Emmett and Travis have gotten lost. Sullivan rushes in rashly to find his lost team members, and specifically Andy, as flashbacks show that he's married her. Pruitt breaks through the roof to ventilate the building to save everyone running out of oxygen, sacrificing himself in the process. This allows the smoke to vent and saves those still in the building, who all exit and realize that there is a vent in the roof where one had been impossible (and Maya at the base of the ladder, crying). Twenty bells toll in honor of the fallen hero, as Andy realizes it was her father who was lost.

After the heroic death of Pruitt, Andy and the rest of the crew mourn his death in different ways. Andy has several lucid dreams. Vic decides on finding a way to raise money for Pruitt's line-of-duty funeral, including forcing other team members to pose for a calendar, because Chief Dixon is blocking it (he considers Pruitt a civilian). Maya is subjected to a review from department brass over Pruitt's death. Jack and Dean are called to a house for a third gas leak report to find that a deaf child was trying to get help for his mother who was being abused by his new step-father. The team works to get the woman help. Warren learns from Emmett that Sullivan suffered an overdose, and Emmett comes out to the station as a gay man.

The calendars are in, Andy is back to work, and Maya's mom has shown up unexpectedly. A cute girl needs help from Dean, and she gives him her number. Maya's mom explains that she has left Maya's father, citing the abuse that Maya has accepted as normal. Station 19 trucks are called to a blaze at a bowling alley where several victims are trapped inside. Meanwhile, Ben presents Sullivan with a cup to submit a drug test specimen in. In a heated conversation, Sullivan admits to Warren that he and Herrera are now married. Warren tells him he needs to tell Chief Dixon everything about the drug use, theft, and overdose. Meanwhile Andy and Jack are trapped inside the bowling alley with seven kids, while the rest of the crew tries to bring down a wall to get to them. Flashbacks show Pruitt and Warren having drinks at a bar and talking, with Pruitt recalling a call early in his career where a drunk driver had caused a horrific accident shortly after a Seattle PD officer had let him go because he was the mayor's son. Pruitt says that that cop later cashed in the favor. Warren and Sullivan speak to the chief about Sullivan's marriage and drug abuse, but not before the chief relents about Pruitt's funeral. Dixon says he doesn't need a drug scandal, so they should pretend like nothing happened. Warren realizes during this that Dixon is the cop from Pruitt's story, and Dixon threatens Ben and Miranda with a "drug ring" scandal. Warren decides to take Dixon down. Sullivan announces to everyone that he and Herrera are married.

A woman wanders into the station covered in blood, saying she thinks she killed "him." She pulls out a knife and asks what she's supposed to do with it. Warren and Jackson Avery respond to the park where the woman says she came from and find a man unresponsive with several knife wounds. They load him up and tell Emmett to drive, but unbeknownst to the surgeons, another woman jumps into the front seat and points a gun at Emmett, telling him to drive. Maya and Carina are having a great day together until Carina brings up Maya's mom. Andy sorts through family photos and boxes full of Pruitt's things. Travis and Vic are sent on strange fire inspections connected to Chief Dixon. At the station, the bloody woman explains to the cops that she was running when someone attacked her and she fought back. The gun-toting woman demands drugs from the surgeons, threatening death for noncompliance. She gets spooked and fires the gun, grazing Avery's leg. She then gets the drugs from the cabinet, runs away, and is violently struck by a truck, dying. Sullivan goes to the review board to report Dixon. In flashbacks, Vic is a community college student struggling with her grandma's death when Pruitt and Station 19 come through for a failing fire inspection, followed by the inevitable death of her theatre director.

Suspended after having turned himself in to the Civil Service Commission, Sullivan is admitted to Grey Sloan for his surgery. Plagued by memories of her last day with her mother and her parents fighting, Andy's attention is split between staying by her husband's side and meeting her aunt Sandra, who has agreed to meet up to talk about her mother. Andy finds comfort in talking to Meredith about her family situation. Meanwhile, the rest of the crew responds to a terrorist bomb threat at Pac-North. While her crew scrambles to defuse a bomb and save precious research, Maya finds the courage to stand up to her father when he openly belittles her in front of her peers. At the scene, Dixon is arrested for fraud and extortion. Travis dumps Emmett after realizing he is not in love with him. Maya makes amends with Jack and Carina, who takes her back. Jack spends time with his improvised family. Feeling they are getting too close to keep his true feelings hidden, Dean tells Vic to move out. As Sullivan wakes up in immense pain, Andy meets Sandra in a motel and is surprised to see her mother alive and well.