Spinal muscular atrophy with lower extremity predominance 2A (SMALED2A) is a rare neuromuscular disorder characterised by muscle weakness predominantly in legs. The disorder is usually diagnosed shortly after birth; affected children have a delayed motor development, waddling gait, difficulties walking, sometimes develop spasticity.^[1][2] Sensation, swallowing and cognitive development are not affected. The disorder is slowly progressive throughout the lifetime.^[1]

The disease is caused by a mutation in the BICD2 gene and is passed on in an autosomal dominant manner.^[1]

There is no known cure for SMALED2A.^{[citation needed]}

• Spinal muscular atrophies
• Spinal muscular atrophy with lower extremity predominance 1
• Spinal muscular atrophy with lower extremity predominance 2B