The Southern Illinois River-to-River Conference (SIRR) is a high school athletic conference represented by 12 schools in southern Illinois. The conference is divided into two divisions. While technically in the same conference each division crowns its own champion, and each winner is regarded as the conference champion as if they were in two separate conferences. Schools are only required to play other schools within their own division although cross-divisional play is very common.

This article relies excessively on references to primary sources. (July 2008)

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Southern Illinois River-to-River Conference

Conference	IHSA
Founded	1993
No. of teams	11
Region	Southern Illinois
Locations

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Seven of the charter members of the River-to-River Conference were members of the old Southwest Egyptian Conference. Around 1991, the Southwest Egyptian was approached by Benton, Herrin, Harrisburg, and West Frankfort for membership; these four schools were concerned over their small size relative to the other members of the South Seven Conference (where all four were then located) and sought out a conference more in line with their size. Massac County (then an independent school) was approached about becoming a member, and in 1993 the Southern Illinois River-to-River Conference was formed.

At the start of the 2010–2011 school year Carterville left the Black Diamond Conference to join the Southern Illinois River-to-River Conference. Chester High School has taken their place in the Black Diamond Conference.^[1]

On June 12, 2020, it was announced that Sparta High School will depart for the Cahokia Conference the 2020–2021 school year, and the 11 remaining members were looking into potential replacements. ^[2]