Sophia of Saxony (died 1244) was a member of the House of Ascania, and the abbess of Gernrode (r.1220–1244).

Sophia was a member of the House of Ascania. Her parents were Bernard III of Saxony and Judith/Jutta of Poland, daughter of Mieszko III of Poland.^[1] Sophia was brought up in the abbey of Gernrode.^[2] Sophia's siblings included Albert I of Saxony and Henry I of Anhalt, the latter of whom was the advocate for the abbey of Gernrode.^[3]

Sophia succeeded Adelaide II as abbess of Gernrode in late 1220. The first recorded reference to Sophia as abbess is found in a charter issued in 1221.^[4]

In order to protect the abbey's wealth from embezzlement or theft, Sophia purchased extensive goods in Rieder. This purchase was confirmed by Sophia's brother, Henry I, in Aschersleben in 1223. A confirmation of all of the abbey's property and rights, issued by Pope Gregory IX in June 1227 also referred to the property in Rieder.^[5]

Sophia most likely died on 16 July 1244.^[6]