Simone Canestrelli (born 11 September 2000) is an Italian professional footballer who plays as a defender for Serie B club Pisa.^[1]

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In July 2019, Canestrelli moved to Serie C club AlbinoLeffe on a free transfer.^[2]

On 1 July 2021, Empoli exercised their right to buy Canestrelli back from AlbinoLeffe.^[3]

On 27 August 2021, he joined Crotone on loan.^[4] On 18 July 2022, Canestrelli was loaned to Pisa.^[5] On 30 January 2023, Pisa exercised their option to make Canestrelli's transfer permanent.^[6] On the next day, he was loaned by Pisa to Como.^[7]