Simon Diedong Dombo (1925–1998) was a Ghanaian politician, teacher and chief. He was a Member of Parliament that represented Jirapa-Lambussie District in the first Parliament of the first and second Republic of Ghana.

Simon was born in 1925. He attended Government Teacher Training College Tamale where he obtained his Teachers' Training Certificate.^{[citation needed]}

As the Douri-Na,^[1][2] he was reputed to be the first educated chieftain in the Upper Region of Ghana.^[3] He was one of the founders of the Northern People's Party. This later merged with the United Party.

During the Second Republic, he was also a member of the first parliament under the membership of the ruling Progress Party. He was elected in the 1969 Ghanaian general elections.^[4] He was Minister for Health and then Minister for Interior^[2][5] in the Busia government.

He was banned from holding elected office by the Supreme Military Council prior to the 1979 elections.^[6] S. D. Dombo was among the early educated chieftains.

He was a Catholic Christian and he had more than 30 children.^[7] He died on 19 March 1998.

• Busia government
• List of MPs elected in the 1969 Ghanaian parliamentary election
• Minister for Health (Ghana)
• Minister for the Interior (Ghana)