Scooby-Doo and Guess Who? is an American animated television series produced by Warner Bros. Animation and the thirteenth television series in the Scooby-Doo franchise. The series is produced by Chris Bailey.

The show first premiered on Boomerang's SVOD service on June 27, 2019,^[2] before making its linear debut on Cartoon Network on July 8, 2019, and on the Boomerang channel on October 1, 2020. The series moved to HBO Max (now Max) and the remaining second-season episodes were released on October 1, 2021.^[3]

Following a similar premise to The New Scooby-Doo Movies, the series focuses on the Mystery Inc. gang as they solve mysteries while encountering and being assisted by various celebrities and fictional characters, including crossovers with DC Comics and Hanna-Barbera characters, and even the Scooby gang's very own voice actors.

Chris Bailey was directing an independent film called Paws of Fury: The Legend of Hank. However, the movie faced a troubled production, so Chris called Sam Register and told Sam that the movie hit a roadblock so he became available to make a show. They frequently talked about doing some sort of “Cartoony Superheroey Thing”, so Sam sent that message to Jay Bastian, the Senior Vice President of Series for Warner Bros. Animation. After meeting with Jay, Chris was given a project that actually fit in with what he wanted to make and he started developing it, but right before turning in the script, the project was canceled in the wake of AT&T's purchase of Time Warner. During one of Chris's later meetings with Jay the latter asked him about Scooby-Doo. Chris told him that he watched the shows as a kid, and that he tuned in for them "every Saturday morning for three years before ultimately moving on to other stuff". While Chris loved the series and the characters, he never really thought of himself as a "Scooby-Doo guy", so took time to think and came back to WB, and one of the things that really stuck with him as a kid were the celebrity guest stars and he thought:

"Well, what if we did like sort of a contemporary version of Scooby-Doo totally went back to basics with the structure and just sort of milk the clichés of style, not something that was done because or it was done at the time because of budget, but overtime those things became style, so let's embrace those things and let's not do too much animation that's three-quarter into camera, let's like stage things for depth but keep the animation left to right and right to left and let's always use Scooby and Shaggy's classic run and use the same takes things like that."

Jay liked the idea and the original concept of the show but instead of guest starring celebrities it was originally going to include guests from the Hanna-Barbera library with potential guests including Jonny Quest and Frankenstein Jr. and The Impossibles.^[4] In one of conversations during development, Sam Register said that he really wanted to do a show with Steve Urkel, which turned out to be one of Chris's favorite shows. This marked a shift towards more human guest stars with cartoon guests existing as a fallback option. The crew had a desire to invite Michael Phelps to do an episode with Jabberjaw but he passed on it so the episode was never produced.

The first season was released on DVD on January 19, 2021, by Warner Bros. Home Entertainment.^[6] The second season was released on DVD on June 28, 2022.^[7]