Saint Anthony Main is an stretch of buildings on Main Street across from Saint Anthony Falls in the Nicollet Island/East Bank neighborhood of Minneapolis. Commonly the area is associated with Northeast, Minneapolis as it is actually northeast of downtown on the east side of the Mississippi River. It opened as a festival marketplace in the 1980s.

In 1968, Architect Peter Nelson Hall purchased Pracna, which at the time was a machine shop, revitalized it back into a restaurant, and brought a focus in Minneapolis back to the Riverfront. This started a revitalization movement on Main Street.

The area underwent a resurgence during the condominium boom in the early 2000s with several condo projects built in and around the area. It is now home to a movie theater, four bars and restaurants, a small cafe, design firms, and a Segway tour operator.^[1][2]

Saint Anthony Main sits on the other side of Central Avenue from Riverplace, a housing and office complex. It fronts the river at Saint Anthony Falls, the only waterfall on the Mississippi River, and sits across from the Main Street Station, host of the Water Power Park, which opened in Spring 2007.^[3]

Some of the buildings in the area date from the 1850s when the Village of Saint Anthony on the northeast side of the Mississippi River was still separate from Minneapolis itself. Several are contributing properties to the Saint Anthony Falls Historic District:^[4]

• Pracna Building, 117 Main Street SE (1890, now Pracna on Main)
• Salisbury & Satterlee Company Complex, 201-205 and 219 Main Street SE (1885, now Vic's Dining and Tuggs)
• Upton Block/ Union Iron Works, 129 Main Street SE (1855)
• Martin and Morrison Block, 127-129 Main Street SE (1858)

There are newer buildings in the area such as Phoenix on the River and the Mill and Main apartments and the Stone Arch Apartments complexes.^[5][6][7] The Pillsbury A-Mill was renovated and converted into new apartments including the A-Mill Artist lofts.^[8]