SLC26A6

SLC26A6

SLC26A6

Protein-coding gene in the species Homo sapiens

Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene.[5][6][7] It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.[8]

Quick Facts Identifiers, Aliases ...

This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Several alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been described, but the full-length nature of some of these variants has not been determined.[7]

Associated diseases

Diseases associated with SLC26A6 include sialolithiasis and urolithiasis.[9]

See also

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000225697 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000023259 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Lohi H; Kujala M; Kerkela E; Saarialho-Kere U; Kestila M; Kere J (Jan 2001). "Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger". Genomics. 70 (1): 102–12. doi:10.1006/geno.2000.6355. PMID 11087667.
  6. [6]
    Waldegger S; Moschen I; Ramirez A; Smith RJ; Ayadi H; Lang F; Kubisch C (Mar 2001). "Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family". Genomics. 72 (1): 43–50. doi:10.1006/geno.2000.6445. PMID 11247665.
  7. [7]
    "Entrez Gene: SLC26A6 solute carrier family 26, member 6".
  8. [8]
    Wang, Zhaohui; Tong Wang; Snezana Petrovic; Biguang Tuo; Brigitte Riederer; Sharon Barone; John N. Lorenz; Ursula Seidler; Peter S. Aronson; Manoocher Soleimani (April 2005). "Renal and intestinal transport defects in Slc26a6-null mice". American Journal of Physiology. Cell Physiology. 4. 288 (4): C957–C965. doi:10.1152/ajpcell.00505.2004. PMID 15574486. S2CID 23214608.
  9. [9]
    "SLC26A6 Gene - GeneCards | S26A6 Protein | S26A6 Antibody". www.genecards.org. Retrieved 2021-05-06.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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