SIRPG

SIRPG

SIRPG

Protein-coding gene in the species Homo sapiens

Signal-regulatory protein gamma is a protein that in humans is encoded by the SIRPG gene.[5][6][7] SIRPG has also recently been designated CD172G (cluster of differentiation 172G).

Quick Facts Available structures, PDB ...

The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described.[7]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000089012 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000037902 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Ichigotani Y, Matsuda S, Machida K, Oshima K, Iwamoto T, Yamaki K, Hayakawa T, Hamaguchi M (Jan 2001). "Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family". J Hum Genet. 45 (6): 378–82. doi:10.1007/s100380070013. PMID 11185750.
  6. [6]
    van den Berg TK, van Beek EM, Buhring HJ, Colonna M, Hamaguchi M, Howard CJ, Kasuga M, Liu Y, Matozaki T, Neel BG, Parkos CA, Sano S, Vignery A, Vivier E, Wright M, Zawatzky R, Barclay AN (Dec 2005). "A nomenclature for signal regulatory protein family members". J Immunol. 175 (12): 7788–9. doi:10.4049/jimmunol.175.12.7788. PMID 16339511.
  7. [7]
    "Entrez Gene: SIRPG signal-regulatory protein gamma".

Further reading

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Signal-regulatory protein gamma (SIRPG)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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