SEMA5A

SEMA5A

SEMA5A

Protein-coding gene in the species Homo sapiens

Semaphorin-5A is a protein that in humans is encoded by the SEMA5A gene.[5][6][7]

Quick Facts Identifiers, Aliases ...

Members of the semaphorin protein family, such as SEMA5A, are involved in axonal guidance during neural development.[7][5]

Semaphorin 5A also plays a role in autism, reducing the ability of neurons to form connections with other neurons in certain brain regions.[8][9]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000112902 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000022231 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Adams RH, Betz H, Püschel AW (June 1996). "A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis". Mechanisms of Development. 57 (1): 33–45. doi:10.1016/0925-4773(96)00525-4. PMID 8817451. S2CID 17827262.
  6. [6]
    Simmons AD, Püschel AW, McPherson JD, Overhauser J, Lovett M (January 1998). "Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval". Biochemical and Biophysical Research Communications. 242 (3): 685–691. doi:10.1006/bbrc.1997.8027. PMID 9464278.
  7. [7]
    "Entrez Gene: SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A".
  8. [8]
    Mosca-Boidron AL, Gueneau L, Huguet G, Goldenberg A, Henry C, Gigot N, et al. (June 2016). "A de novo microdeletion of SEMA5A in a boy with autism spectrum disorder and intellectual disability". European Journal of Human Genetics. 24 (6): 838–843. doi:10.1038/ejhg.2015.211. PMC 4867450. PMID 26395558.
  9. [9]
    Carulli D, de Winter F, Verhaagen J (2021). "Semaphorins in Adult Nervous System Plasticity and Disease". Frontiers in Synaptic Neuroscience. 13: 672891. doi:10.3389/fnsyn.2021.672891. PMC 8148045. PMID 34045951.

Further reading


Stub icon

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.
Share this article:

This article uses material from the Wikipedia article SEMA5A, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.