The Rutas Express Guatemala (English: Express Routes), is an Express Public Transit system that operates from the Mixco Municipality, west of Guatemala City. This service serves local residents in Mixco and the South-west end of Guatemala City, and provides some connections to Transmetro lines.^[1] Mixco is the third most populous city in the metropolitan region surrounding Guatemala City,^[2] and was severely under served by public transit from private operators in recent years.

• On February 25, 2017, Mixco began service on the first express line, named "Express Roosevelt" with 10 articulated buses.^[3] The name stems from its mid-way point at Roosevelt, an important interchange in Guatemala city.
• On December 17, 2017, Mixco began service on the second line, named "Express Naranjo" with refurbished Transurbano units and refurbished retired buses from North American public transit agencies.^[4] The name stems from its routing which travels on Naranjo boulevard.
• On April 27, 2019, Mixco began service on the third line, named "Express Minervas" with 20 new, and refurbished units.^[5] The name stems from its origin at the Minervas community in Mixco.

Payment is made exclusively via a smart card. When the service was inaugurated, Mixco was the only issuer of smart cards compatible with the system.^[6] However, after Guatemala city launched its own smart card for the Transmetro network, Mixco began accepting payment by the Trajeta Ciudadana from Guatemala City. The price for 1 ride using the Mixco Card is GTQ2.50, while the cost of 1 ride using the Tarjeta Ciudadana is GTQ2.00.^[7]