The Roman Catholic Diocese of Xai-Xai (Latin: Xai-Xaien(sis)) is a diocese located in the city of Xai-Xai in the Ecclesiastical Province of Maputo in Mozambique.

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• 19 June 1970: Established as Diocese of João Belo from the Metropolitan Archdiocese of Lourenço Marques
• 1 October 1976: Renamed as Diocese of Xai-Xai

The cathedral is the Catedral São João Baptista (Cathedral of St. John the Baptist) in Xai-Xai.

• Roman Catholicism in Mozambique