Ras_p21_protein_activator_2

Ras p21 protein activator 2

Ras p21 protein activator 2

Protein-coding gene in the species Homo sapiens

RAS p21 protein activator 2 is a protein that in humans is encoded by the RASA2 gene. [5]

Quick Facts RASA2, Identifiers ...

Function

The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014].

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000155903 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000032413 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    "Entrez Gene: RAS p21 protein activator 2". Retrieved 2018-09-14.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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