Phillip T. and Susan M. Ragon Institute is a medical institute founded in 2009 at the Massachusetts General Hospital (MGH) by the funding from founder and CEO of InterSystems Phillip Ragon and his wife Susan Ragon to find vaccines for diseases of the immune system, particularly HIV/AIDS.^[1] The institute includes scientists from Harvard University, the Massachusetts Institute of Technology (MIT) and the MGH, a level I trauma center which is the largest teaching hospital affiliated with Harvard Medical School.

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The Ragon Institute's scientific leadership comprises a diverse group of immunologists, geneticists, infectious disease specialists and computational and systems biologists from the MGH, MIT, Harvard, the Broad Institute, Harvard-affiliated hospitals in Boston and from other institutions housing satellite collaborators around the country.

The Ragon Institute was founded in February 2009 through a $100 million gift – the largest gift in Massachusetts General Hospital (MGH) history^[2] – from the Phillip T. and Susan M. Ragon Institute Foundation. Administratively based at MGH, the Ragon Institute incorporates the work of the Partners AIDS Research Center at MGH. Instead of the typical academic approach, in which individual scientists work independently, the Ragon Institute includes engineering disciplines to facilitate new experimental approaches and incorporate fresh ways of viewing complex biological systems, with the goal of rapidly advancing innovative, interdisciplinary research to revolutionize the field of immunology.^{[citation needed]}

In January 2013, the Ragon Institute completed its relocation to 400 Technology Square in Cambridge, Massachusetts.^[3]

Researchers, staff, and collaborators occupy approximately 74,675 sq ft of the facility at 400 Technology Square, Cambridge, Massachusetts, consisting of floors 7–10, half the 1st floor, and 3,000 sq ft on the basement level. The building also features a Biosafety Level 3 (BL3) lab, which will provide scientists in the community access to a dedicated 12-color high-speed cell sorter and microscopy. The first floor has a 160-seat auditorium with audio-visual and conferencing capabilities which is used for weekly seminars as well as community events.^{[citation needed]}